IMGT Repertoire (IG and TR)

Alignment of alleles: house mouse (Mus musculus) TRAV4-2 and TRAV4D-2

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
Dots indicate gaps according to the IMGT unique numbering.
Blanks at the 5' and/or 3' end indicate partial sequences.
Asterisk (*) in the sequence indicate a STOP-CODON.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
Colours are according to Color menu for mutations, Color menu for sequence alignments and Color menu for splicing types.
The nucleotide (s) in bold and colored in purple (splicing frame 1) or green (splicing frame 2) from the DONOR splice site are added at the beginning of the following exon in order to obtain and to complete the first CODON of the DOMAIN or REGION resulting from the splicing site. These first CODONs are in bold and colored in purple (splicing frame 1) or green (splicing frame 2)
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown in green
Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.
                                                                                                                             
                                             
                                              1   2   3   4   5   6   7   8   8A  9   10  11  12  13  14  15  16  17  18  19 
                                              G   M   P   V   E   Q   N   P       P   A   L   S   L   Y   E   G   A   D   S  
  AC004407   TRAV4-2*01  F V-REGION gDNA     gga atg ccg gtg gaa cag aat cct ... cca gcc ctg agt ctt tat gaa gga gct gac tct 

                                                                                                                             
  AE007512   TRAV4-2*01  F V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                                             
  AE008684   TRAV4-2*01  F V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                                      E      
  AF259073   TRAV4D-2*01 P V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --g --- 

                                                                                                                      E      
  AE007512   TRAV4D-2*01 P V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --g --- 

                                                                                                                      E      
  AE008683   TRAV4D-2*01 P V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --g --- 

                                                                                                                      E      
  AC122813   TRAV4-2*02  F V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --g --- 

                                                                                                                      E      
  IMGT000082 TRAV4-2*02  F V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --g --- 

                                                                                                                      E      
  M87848     TRAV4-2*02  F V-REGION cDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --g --- 

                                                                                                                      E      
  IMGT000082 TRAV4D-2*02 P V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --g --- 



                                                                         ___________________CDR1-IMGT____________________    
                                             
                                              20  21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39 
                                              G   L   R   C   N   F   S   T   T   M                               K   S   V  
  AC004407   TRAV4-2*01  F V-REGION gDNA     ggt ctg aga tgc aat ttt tct acc acc atg ... ... ... ... ... ... ... aaa agt gtc 

                                                                                                                             
  AE007512   TRAV4-2*01  F V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ... --- --- --- 

                                                                                                                             
  AE008684   TRAV4-2*01  F V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ... --- --- --- 

                                                                                                                      G      
  AF259073   TRAV4D-2*01 P V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ... --- g-- --- 

                                                                                                                      G      
  AE007512   TRAV4D-2*01 P V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ... --- g-- --- 

                                                                                                                      G      
  AE008683   TRAV4D-2*01 P V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ... --- g-- --- 

                                                                                                                      G      
  AC122813   TRAV4-2*02  F V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ... --- g-- --- 

                                                                                                                      G      
  IMGT000082 TRAV4-2*02  F V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ... --- g-- --- 

                                                                                                                      G      
  M87848     TRAV4-2*02  F V-REGION cDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ... --- g-- --- 

                                                                                                                      G      
  IMGT000082 TRAV4D-2*02 P V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ... --- g-- --- 



                                                                                                             _______________C
                                             
                                              40  41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59 
                                              Q   W   F   Q   Q   N   H   R   G   R   L   I   T   L   F   Y   L   A   Q      
  AC004407   TRAV4-2*01  F V-REGION gDNA     cag tgg ttt caa caa aat cac aga ggc aga ctt atc act ctg ttt tac ctg gct caa ... 

                                                                                                                             
  AE007512   TRAV4-2*01  F V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... 

                                                                                                                             
  AE008684   TRAV4-2*01  F V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... 

                                                                                      F                                      
  AF259073   TRAV4D-2*01 P V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- t-- --- --- --- --- --- --- --- --- ... 

                                                                                      F                                      
  AE007512   TRAV4D-2*01 P V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- t-- --- --- --- --- --- --- --- --- ... 

                                                                                      F                                      
  AE008683   TRAV4D-2*01 P V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- t-- --- --- --- --- --- --- --- --- ... 

                                                                                                                             
  AC122813   TRAV4-2*02  F V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... 

                                                                                                                             
  IMGT000082 TRAV4-2*02  F V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... 

                                                                                                                             
  M87848     TRAV4-2*02  F V-REGION cDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... 

                                                                                      F                                      
  IMGT000082 TRAV4D-2*02 P V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- t-- --- --- --c --- --- --- --- --- ... 



                                             DR2-IMGT________________                                                        
                                             
                                              60  61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79 
                                                              G   T   K   E   N                       G   R   L   K   S   T  
  AC004407   TRAV4-2*01  F V-REGION gDNA     ... ... ... ... gga aca aag gag aat ... ... ... ... ... gga agg tta aag tca aca 

                                                                                                                             
  AE007512   TRAV4-2*01  F V-REGION gDNA     ... ... ... ... --- --- --- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                                                                             
  AE008684   TRAV4-2*01  F V-REGION gDNA     ... ... ... ... --- --- --- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                                                                             
  AF259073   TRAV4D-2*01 P V-REGION gDNA     ... ... ... ... --- --- --- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                                                                             
  AE007512   TRAV4D-2*01 P V-REGION gDNA     ... ... ... ... --- --- --- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                                                                             
  AE008683   TRAV4D-2*01 P V-REGION gDNA     ... ... ... ... --- --- --- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                                                                             
  AC122813   TRAV4-2*02  F V-REGION gDNA     ... ... ... ... --- --- --- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                                                                             
  IMGT000082 TRAV4-2*02  F V-REGION gDNA     ... ... ... ... --- --- --- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                                                                             
  M87848     TRAV4-2*02  F V-REGION cDNA     ... ... ... ... --- --- --- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                                                                             
  IMGT000082 TRAV4D-2*02 P V-REGION gDNA     ... ... ... ... --- --- --- --- --- ... ... ... ... ... --- --- --- --- --- --- 



                                                                                                                             
                                             
                                              80  81  82  83  84 84A  85  86  87  88  89  90  91  92  93  94  95  96  97  98 
                                              F   N   S   K   E       R   Y   S   T   L   H   I   K   D   A   Q   L   E   D  
  AC004407   TRAV4-2*01  F V-REGION gDNA     ttc aat tct aag gag ... cgc tac agc acc ctg cac atc aag gat gca cag ctg gag gac 

                                                                                                                             
  AE007512   TRAV4-2*01  F V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                                             
  AE008684   TRAV4-2*01  F V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                          *                                       R                          
  AF259073   TRAV4D-2*01 P V-REGION gDNA     --- --- --- t-- --- ... --- --- --- --- --- --- --- -g- --- --- --- --- --- --- 

                                                          *                                       R                          
  AE007512   TRAV4D-2*01 P V-REGION gDNA     --- --- --- t-- --- ... --- --- --- --- --- --- --- -g- --- --- --- --- --- --- 

                                                          *                                       R                          
  AE008683   TRAV4D-2*01 P V-REGION gDNA     --- --- --- t-- --- ... --- --- --- --- --- --- --- -g- --- --- --- --- --- --- 

                                                                                                                             
  AC122813   TRAV4-2*02  F V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                                             
  IMGT000082 TRAV4-2*02  F V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                                             
  M87848     TRAV4-2*02  F V-REGION cDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                          *                                       R                          
  IMGT000082 TRAV4D-2*02 P V-REGION gDNA     --- --- --- t-- --- ... --- --- --- --- --- --- --- -g- --- --- --- --- --- --- 



                                                                     ___CDR3-IMGT____
                                             
                                              99 100 101 102 103 104 105 106 107 
                                              S   G   T   Y   F   C   A   A   E  
  AC004407   TRAV4-2*01  F V-REGION gDNA     tca ggc act tac ttc tgt gct gct gag g

                                                                                 
  AE007512   TRAV4-2*01  F V-REGION gDNA     --- --- --- --- --- --- --- --- --- -

                                                                                 
  AE008684   TRAV4-2*01  F V-REGION gDNA     --- --- --- --- --- --- --- --- --- -

                                                                                 
  AF259073   TRAV4D-2*01 P V-REGION gDNA     --- --- --- --- --- --c --- --- --- -

                                                                                 
  AE007512   TRAV4D-2*01 P V-REGION gDNA     --- --- --- --- --- --c --- --- --- -

                                                                                 
  AE008683   TRAV4D-2*01 P V-REGION gDNA     --- --- --- --- --- --c --- --- --- -

                                                                          V      
  AC122813   TRAV4-2*02  F V-REGION gDNA     --- --- --- --- --- --- --- -t- --- -

                                                                          V      
  IMGT000082 TRAV4-2*02  F V-REGION gDNA     --- --- --- --- --- --- --- -t- --- -

                                                                          V      
  M87848     TRAV4-2*02  F V-REGION cDNA     --- --- --- --- --- --- --- -t- --- 

                                                                                 
  IMGT000082 TRAV4D-2*02 P V-REGION gDNA     --- --a --- --- --- --c --- --- --- -
Legend:
*: STOP-CODON
This alignment of allele is generated by IMGT/OutilAllele (Mehdi Yousfi, Chantal Ginestoux, Perrine Pégorier and Patrice Duroux).
Created:: 05/09/2022
Last updated:: 22/09/2023
Authors:: Guilhem Zeitoun